Charles J Smith Selected Research

Bombesin Receptors (Bombesin Receptor)

1/2021	Preclinical Evaluation of Novel 64Cu-Labeled Gastrin-Releasing Peptide Receptor Bioconjugates for PET Imaging of Prostate Cancer.
1/2018	Design, Synthesis, and in Vitro and in Vivo Evaluation of High Affinity and Specificity Near-Infrared Fluorescent Bombesin Antagonists for Tumor Imaging.
1/2018	Peptide-Based Radiopharmaceuticals for Molecular Imaging of Prostate Cancer.
1/2016	Lutetium-177 Labeled Bombesin Peptides for Radionuclide Therapy.
2/2015	Characterization and evaluation of DOTA-conjugated Bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy.
4/2014	Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer.
6/2013	Near-infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases.
7/2012	Positron-emission tomography (PET) imaging agents for diagnosis of human prostate cancer: agonist vs. antagonist ligands.
6/2012	PET of tumors expressing gastrin-releasing peptide receptor with an 18F-labeled bombesin analog.
4/2012	64Cu-NO2A-RGD-Glu-6-Ahx-BBN(7-14)NH2: a heterodimeric targeting vector for positron emission tomography imaging of prostate cancer.

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Charles J Smith Research Topics

Disease

30	Neoplasms (Cancer) 01/2021 - 01/2005
15	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 04/2006
3	Glioblastoma (Glioblastoma Multiforme) 07/2018 - 02/2014
3	Breast Neoplasms (Breast Cancer) 01/2010 - 05/2007
2	Melanoma (Melanoma, Malignant) 02/2012 - 03/2007
2	Carcinoma (Carcinomatosis) 01/2012 - 01/2010
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2019
1	Neoplasm Metastasis (Metastasis) 06/2013
1	Lymphatic Metastasis 06/2013
1	Colorectal Neoplasms (Colorectal Cancer) 07/2010
1	Pancreatic Neoplasms (Pancreatic Cancer) 05/2007
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 04/2006

Drug/Important Bio-Agent (IBA)

19	Peptides (Polypeptides)IBA 01/2021 - 01/2005
15	Bombesin Receptors (Bombesin Receptor)IBA 01/2021 - 04/2006
13	BombesinIBA 07/2018 - 03/2005
8	LigandsIBA 01/2021 - 07/2007
6	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA 01/2021 - 07/2007
5	IntegrinsIBA 07/2018 - 03/2007
5	Gastrin-Releasing PeptideIBA 01/2010 - 04/2006
4	RadiopharmaceuticalsIBA 01/2018 - 02/2009
4	Biological ProductsIBA 04/2014 - 03/2005
4	triazacyclononaneIBA 04/2014 - 02/2009
3	1- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA 01/2021 - 04/2014
3	AcidsIBA 04/2014 - 10/2010
3	Aminocaproic Acid (6 Aminocaproic Acid)FDA LinkGeneric 04/2014 - 10/2010
3	Chelating AgentsIBA 02/2012 - 03/2005
2	AntigensIBA 01/2018 - 04/2014
2	Biomarkers (Surrogate Marker)IBA 01/2016 - 04/2014
2	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 02/2015 - 07/2010
2	Copper-64IBA 04/2014 - 10/2010
2	arginyl-glycyl-aspartic acidIBA 04/2012 - 03/2007
2	Peptide LibraryIBA 02/2012 - 01/2012
2	Radioisotopes (Radionuclides)IBA 05/2008 - 09/2007
1	cupric chloride (copper(II) chloride)FDA Link 01/2021
1	beta-microseminoproteinIBA 01/2021
1	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2019
1	5-aminovaleric acidIBA 04/2014
1	leucylmethionineIBA 04/2012
1	Glutamic Acid (Glutamate)FDA Link 04/2012
1	glycylhistidineIBA 04/2012
1	beta-AlanineIBA 10/2010
1	4-Aminobenzoic Acid (4 Aminobenzoic Acid)IBA 10/2010
1	Guanylate Cyclase (Guanylyl Cyclase)IBA 07/2010
1	Enterotoxins (Enterotoxin)IBA 07/2010
1	Enterotoxin ReceptorsIBA 07/2010
1	bombesin (7-14)IBA 01/2010
1	(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)IBA 02/2009
1	Fluorescent Dyes (Fluorescent Probes)IBA 05/2007
1	Integrin alphaVbeta3IBA 03/2007
1	VA 061 (VA061)IBA 04/2006
1	AndrogensIBA 04/2006
1	MetalsIBA 03/2005
1	Pharmaceutical PreparationsIBA 01/2005

Therapy/Procedure

6	Therapeutics 01/2018 - 04/2006
3	Intravenous Injections 07/2018 - 02/2014
3	Radiotherapy 01/2018 - 04/2006
2	Precision Medicine 01/2021 - 07/2018
1	Drug Therapy (Chemotherapy) 04/2006